Chinese Herbal Decoction “Kuan Sin Yin” Improves Abnormal Liver Function of Hepatitis C Patients
Hepatitis C is prevalent in Taiwan, where there are about 400 thousand hepatitis C carriers at present. The hepatitis C virus is an important cause of chronic hepatitis, liver cirrhosis and liver cancer, with its importance second only to the hepatitis B virus. Though there are antiviral drugs with high efficacy abroad, their high prices often drive patients to seek treatment by means of traditional Chinese medicine, herbal medicine and health foods instead. Currently, there are only occasional reports about the efficacy of herbal medicines, most of which lack a rigorous study design or are mere case reports.Linsen Chinese Medicine and Kunming Branch of the Taipei City Hospital cooperate with the Institute of Traditional Medicine, National Yang-Ming University, aiming to evaluate whether the Chinese herbal decoction “Kuan Sin Yin” can improve the liver function of hepatitis C patients and affect their viral load.
Based on the theory of invigorating qi and strengthening the spleen, “Kuan Sin Yin” can improve the abnormal liver function of hepatitis C patients and then decrease the viral load in the serum. The decoction is composed of seven Chinese herbs, including: dangshen (Codonopsis pilosula), baizhu (Atractylodes), fuling (Poria cocos) and licorice root. Fifty-seven subjects were recruited in Linsen Chinese Medicine and Kunming Branch of the Taipei City Hospital from January to December 2013 and completed the whole test. These subjects were randomly divided into two groups, namely the test group administered with the original formula of Kuan Sin Yin and the control group with Kuan Sin Yin diluted 16 times; all of them drank one packet of the decoction after breakfast every morning. The clinical test lasted 6 weeks.
After 6 weeks’ treatment, the test group with the original formula of Kuan Sin Yin had significantly improved liver function, with the reduction of serum GPT by 29.7% and the reduction of serum GOT by 24.4%; the differences between the two groups were statistically significant. Meanwhile, the decoction also decreased RNA viral load of serum HCV by 0.3 log IU/mL, and the difference between the two groups was also statistically significant. Moreover, both the original formula and diluted decoction had no side effects. The research findings have been accepted by the Complementary Therapy in Medicine, an internationally prestigious journal, which will be published this year.
The previous studies of the team showed that Kuan Sin Yin could improve abnormal liver function of Hepatitis B patients, while the current research findings proved that Kuan Sin Yin could improve abnormal liver function of Hepatitis C patients and reduce their Triglyceride by 16.9 mg/dL.